In addition to the existing strong indications for lepton flavor universality violation in low-energy precision experiments, the CMS Collaboration at CERN recently released an analysis of nonresonant dilepton pairs which could constitute the first sign of lepton flavor universality violation in high-energy searches at the LHC. In this article, we show that the Cabibbo-angle anomaly, an (apparent) violation of first row and column Cabibbo-Kobayashi-Maskawa (CKM) matrix unitarity with $\approx 3\sigma$ significance, and the CMS result can be correlated and commonly explained in a model-independent way by the operator $[Q_{\ell q}^{\left(3\right)}{]}_{1111}=({\overline{\ell }}_1{\gamma }^{\mu }{\sigma }^I{\ell }_1\left)\right({\overline{q}}_1{\gamma }_{\mu }{\sigma }^I{q}_1)$. This is possible without violating the bounds from the nonresonant dilepton search of ATLAS (which interestingly also observed slightly more events than expected in the electron channel) nor from $R\left(\pi \right)=\pi \to \mu \nu /\pi \to e\nu$. We find a combined preference for the new physics hypothesis of $4.5\sigma$ and predict $1.0004<R\left(\pi \right)<1.0009$ (95% C.L.) which can be tested in the near future with the forthcoming results of the PEN experiment.