A search for proton decay into $e^{+}/{\mu }^{+}$ and a $\eta$ meson has been performed using data from a $0.373\mathrm{Mton}·\mathrm{year}$ exposure (6050.3 live days) of Super-Kamiokande. Compared to previous searches this work introduces an improved model of the intranuclear $\eta$ interaction cross section, resulting in a factor of 2 reduction in uncertainties from this source and $\sim 10\%$ increase in signal efficiency. No significant data excess was found above the expected number of atmospheric neutrino background events resulting in no indication of proton decay into either mode. Lower limits on the proton partial lifetime of $1.4\times {10}^{34}\mathrm{years}$ for $p\to e^{+}\eta$ and $7.3\times {10}^{33}\mathrm{years}$ for $p\to {\mu }^{+}\eta$ at the 90% CL were set. These limits are around 1.5 times longer than our previous study and are the most stringent to date.