We construct new classes of solutions describing generic off-diagonal deformations of regular Schwarzschild black holes (BHs) in general relativity (GR). Examples of such (primary) diagonal metrics reducing the Einstein equations to integrable systems of nonlinear ordinary differential equations were studied in a recent work by Casadio et al. (Phys Rev D 111:064036, 2025). We develop and apply our anholonomic frame and connection deformations method, which allows us to generate new classes of target off-diagonal solutions. Ansatz that reduces the gravitational field equations to systems of (exactly or parametric) integrable systems of nonlinear partial differential equations are used. We find and analyze certain families of deformed regular BHs containing an off-diagonal de Sitter condensate encoding solitonic vacuum configurations, with possible deformations of horizons and/or gravitational polarizations of constants. We emphasize that general off-diagonal solutions do not involve certain hypersurface or holographic configurations. This means that the Bekenstein–Hawking thermodynamic paradigm is not applicable for characterizing the physical properties of such target regular solutions. We argue that the concept of G. Perelman’s entropy and relativistic geometric flow thermodynamics is more appropriate. Using nonlinear symmetries involving effective cosmological constants, we show how to compute thermodynamic variables for various classes of physically essential solutions in GR.